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Drosophila Circadian Clock Model Download
Eight exsisting Drosophila circadian clock models have been implemented on E-Cell SE 3. These models are listed below and you can download them. The author name links the description of the model. Six models implemented in SBML are also available.
Single Feedback Loop Models
Goldbeter, 1995
- Download :
- [ E-Cell SE 3 ] [ SBML ]
- Reference :
- Goldbeter, A. (1995). A model for circadian oscillations in the Drosophila period protein (PER). Proc R Soc Lond B Biol Sci 261, 319-324.
Tyson et al., 1999
- Download :
- [ E-Cell SE 3 ] [ SBML ]
- Reference :
- Tyson, J. J., Hong, C. I., Thron, C. D., and Novak, B. (1999). A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM. Biophys J 77, 2411-2417.
Scheper et al., 1999
- Download :
- [ E-Cell SE 3 ] [ SBML ]
- Reference :
- Scheper, T. O., Klinkenberg, D., van Pelt, J., and Pennartz, C. (1999). A model of molecular circadian clocks: multiple mechanisms for phase shifting and a requirement for strong nonlinear interactions. J Biol Rhythms 14, 213-220.
Leloup et al., 1999
- Download :
- [ E-Cell SE 3 ]
- Reference :
- Leloup, J. C., and Goldbeter, A. (1999). Chaos and birhythmicity in a model for circadian oscillations of the PER and TIM proteins in drosophila. J Theor Biol 198, 445-459.
Petri et al., 2001
- Download :
- [ E-Cell SE 3 ] [ SBML ]
- Reference :
- Petri, B., and Stengl, M. (2001). Phase response curves of a molecular model oscillator: implications for mutual coupling of paired oscillators. J Biol Rhythms 16, 125-141.
Interlocked Feedback Loop Models
Ueda et al., 2001
- Download :
- [ E-Cell SE 3 ]
- Reference :
- Ueda, H. R., Hagiwara, M., and Kitano, H. (2001). Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm. J Theor Biol 210, 401-406.
Smolen et al., 2002
- Download :
- [ E-Cell SE 3 ] [ SBML ]
- Reference :
- Smolen, P., Baxter, D. A., and Byrne, J. H. (2002). A reduced model clarifies the role of feedback loops and time delays in the Drosophila circadian oscillator. Biophys J 83, 2349-2359.
Smolen et al., 2004
- Download :
- [ E-Cell SE 3 ] [ SBML ]
- Reference :
- Smolen, P., Hardin, P. E., Lo, B. S., Baxter, D. A., and Byrne, J. H. (2004). Simulation of Drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK. Biophys J 86, 2786-2802.
Download All Models
- 8 Models implemented on E-Cell SE 3 compiled by Y.Ogawa [ .tar.gz ][ .zip ]
- 6 Models implemented in SBML compiled by : T.Ishida [ .tar.gz ][ .zip ]
README ( Running the Model )
You can see README here.
